Home' Australian Pharmacist : Australian Pharmacist May 2014 Contents Australian Pharmacist May 2014 I ©Pharmaceutical Society of Australia Ltd.
OTC analgesics can provide high levels
of efficacy in acute pain, according to
international pain expert Professor
Andrew Moore from Oxford University
in the UK.
Speaking at presentations in Sydney
and Canberra last month, he said that
analgesic drug formulation had a
marked effect on the speed of pain relief
and there was also growing evidence
that analgesics for acute pain at OTC
doses should be taken without food.
'When it comes to chronic pain it is
important to match the right pain drug
with the patient. When it comes to pain
relief people want one thing -- for their
pain to be reduced quickly,' he said.
Professor Moore said that a re-
examination of existing data such as
Cochrane reviews of postoperative pain
and pooled analysis of other trial data
sets from a patient outcome perspective
had provided new insights into how
to manage tension-type headache,
the most common form of head ache.
This had shown that some formulations
of analgesic drugs worked much faster
than the standard formulation.
He said the time taken to reach
maximum plasma concentration by fast
acting formulations such as ibuprofen
as a lysine salt, gelatin capsule,
effervescent solution or arginine salt
was much faster than with the standard
formulation and the effect lasted longer,
and needed smaller doses.
'A common misconception with
analgesics is that they must be taken
with food, however there is growing
evidence that analgesics for acute pain
should not be taken with food as it
reduces efficacy and may compromise
safety,' he said.
'Taking ibuprofen with food delays
absorption over the first hour and
reduces peak plasma concentration.
The same is true for paracetamol and
Professor Moore said taking ibuprofen
with food reduced the initial pain
intensity, overall pain relief and duration
of effect making it likely that additional
doses of ibuprofen or other analgesia
would be taken. Higher doses of NSAID
are related to adverse events.
He spoke at the Royal North Shore
Hospital in Sydney at a Reckitt Benckiser
hosted educational evening for
community pharmacists. The event was
also streamed live via RB HealthHub for
pharmacists based interstate or unable
to attend in person.
Professor Moore was in Australia as
key note speaker at the Australian Pain
Society conference in Hobart last month.
His Sydney and Canberra presentations
supported by Reckitt Benckiser.
Professor Moore's presentation is online
at: www.rbhealthhub.com.au/moore .
In-pharmacy genetic testing
Chemmart Pharmacy has become the first
pharmacy group to offer a genetic test after
forming a partnership with genetic testing
company, GenesFX Health.
The test, DNAdose, is a once-off,
pharmacogenomic test that identifies
gene variants in four major enzyme
systems and how these genes metabolise
medications. Through a simple cheek
swab, DNAdose provides new information
to consumers and health professionals
about how an individual's genetic
structure will respond to more than 50%
of commonly prescribed medications.
Chemmart Executive Director Jonathan
Layton said that the move into
pharmacogenomics signalled the next
phase in the brand's growth strategy, with a
greater focus on professional services
that enhance the pharmacist's role as the
medicines expert in the community.
'There is no doubt pharmacogenomics
will play a major role in healthcare and
clinical decision-making in the future --
it's just a matter of time.'
Casey Central Chemmart Pharmacy in
Victoria is the first pharmacy to offer
the DNAdose test with some surprising
results in the first six weeks.
Carolyn Wynen said
she didn't expect the
results of her own
DNA test to be so
that a commonly
prescribed medicine would have severe
detrimental effects on her health if
she were to take it at the standard
'I am a pharmacist and I had no idea this
drug could be toxic for my body if taken
at the standard dose. This simple test
could help a huge number of patients
avoid treatments that don't suit them and
find the ones that do-- it could even save
their lives,' she said.
A study by GenesFX Health has found
that 17--25% of people metabolise their
that is the
By Andrew Daniels
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