Home' Australian Pharmacist : Australian Pharmacist Sept 2013 Contents Australian Pharmacist September 2013 I © Pharmaceutical Society of Australia Ltd.
1. Which of the following statements is
a) Recent reviews confirm the benefits of
cranberry capsules (10,000 mg once
daily) in reducing the severity and
duration of symptomatic urinary tract
b) Recent reviews confirm the benefits
of cranberry capsules (10,000 mg
three times daily) in preventing the
recurrence of symptomatic urinary
c) Recent reviews confirm that antibiotics
are significantly more effective than
cranberry products in reducing the
recurrence of urinary tract infections.
d) Recent reviews highlight the
substantial heterogeneity of cranberry
trials and have been unable to confirm
statistically significant reductions in
recurrent urinary tract infections.
2. Which of the following scenarios
would be MOST APPROPRIATE for a
therapeutic trial of cranberry for the
prevention of recurrent UTIs?
a) A 22-year-old female presenting for
the first time with a symptomatic UTI
and concerns about recurrence.
b) A 40-year-old male with a recent
history of cystitis who is currently
taking warfarin and a proton pump
c) A 55-year-old female with a history
of four antibiotic-treated episodes of
cystitis in the past year and a history
d) A 75-year-old male with a history of
three episodes of severe cystitis in the
past year requiring hospitalisation.
3. Which of the following statements is
a) The active components in cranberry
appear to be the coumarins which
prevent bacteria from adhering to
b) Proanthocyanidins (PACs) with type-A
linkages inhibit the adherence of
P-fimbriated Escherichia coli to
c) The therapeutic benefits of cranberry
are due to type-B PACs which result in
the acidification of the urinary tract.
d) Both type-A and type-B PACs acidify
urine and prevent E. coli adhering
to the uroepithelial cells lining the
4. Which of the following lifestyle
recommendations would be
MOST APPROPRIATE for a sexually
active young woman experiencing
a) Abstain from sexual intercourse until
you have experienced at least a six
month period without a UTI.
b) Always wipe genitals from back to
front, and go to the toilet after sexual
c) Wash genitals and go to the toilet
before sexual intercourse, and wash
genitals after sexual intercourse.
d) Take an oral contraceptive pill to assist
in the prevention of recurrent UTIs.
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• The benefits of cranberry products
in reducing the recurrence of UTIs
• More research is required to confirm
which (if any) population groups
most benefit from cranberry
• The proanthocyanidin content and
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