Home' Australian Pharmacist : Australian Pharmacist February 2012 Contents 158 Australian Pharmacist February 2012 I ©Pharmaceutical Society of Australia Ltd.
prostate cancer, may be beneficial in the
initiation, progression and development
of drug resistance stages of prostate
cancer development.23 It was found that
urolithin A is an uncompetitive inhibitor
and urolithin B a non-competitive
inhibitor, each with selectivity of CYP1B1
over CYP1A1, actions which were a
combination of decreasing activity and
interference of expression of the enzyme.
On the other hand, the punicalins and
punicalagins were much more selective of
CYP1A1 over CYP1B1.23
The claimed first clinical trial of PJ in
prostate cancer patients with rising PSA
levels following surgical or radiation
primary therapy, yielded encouraging
results.24 The patients consumed
eight ounces of PJ daily (570 mg total
polyphenol gallic acid equivalents).
The study demonstrated a significant
increase in PSA doubling time, decrease
in cell proliferation, increase in apoptosis,
increase in serum nitric oxide, and
antioxidative effects, all of which can be
taken as useful indicators of anti-prostate
Finally, the development of another
important cancer, hepatocellular
carcinoma, has been found to be effectively
compromised by a pomegranate emulsion,
using a rat model.25 The focus of activity was
its potent antioxidant action upregulating
a number of hepatic nuclear factor E2-
related factor 2 (Nrf2)-controlled protective
In conclusion, I trust I have served an
effective entrée of pomegranate as a food
medicine. This mystic, fruit should be an
important ingredient in future research
investigating phytochemical anticancer
actions. The effectiveness of ellagic acid, its
related compounds and its metabolites, the
urolithins, against various cancers certainly
herald exciting times ahead in oncology.
1. ABC Gardening Australia Flora. Willoughby, NSW; ABC Books
2. Foster S, Johnson RL. Desk reference to nature's medicine.
Washington DC, USA. National Geographic;290--1.
3. American Botanical Council -- Happy New Year card; available
(after registration) at http://abc.herbalgram.org/site/
4. Seeram NP, Aviram M, Zhang Y, et al. Comparison of antioxidant
potency of commonly consumed polyphenol-rich beverages in
th United States. J Agric Food Chem. Feb 2007;56(4):1415--22.
5. Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention
by pomegranate: Laboratory and clinical evidence. Nutr
6. Jurenka J. Therapeutic applications of pomegranate (Punica
granatum L.) A review. Altern Med Rev. Jun 1 2008;13(2):128--44.
7. van Wyk B-E, Wink M. Medicinal Plants of the World. Pretoria,
South Africa 2004. Briza Publications;263.
8. Pelletierine. Phytochemical Dictionary -- A handbook of
bioactive compounds from plants. Eds. Harborne JB & Baxter H.
London1993. Taylor & Francis;252, PD923.
9. Pseudopelletierine. Reference 3; 306, PD1136.
10. Yarnell E, Abascal K, Rountree R. Clinical Botanical Medicine 2nd
edition. 2009. Mary Ann Liebert, NY;177--87.
11. Zhang J, Zhan B, Yao X, et al. Antiviral activity of tannin from the
pericarp of Punica granatum L., against genital Herpes virus in
vitro. Zhongguo Zhong Yao Za Zhi 1995;20(9):556-8, inside back
cover (in Chinese); through reference 10.
12. Su XW, Sangster MY, D'Souza DH. Time-dependent effects
of pomegranate juice and pomegranate polyphenols on
foodborne viral reduction. Foodborne Pathogens and Disease.
13. Seeram NP, Adams LS, Henning SM, et al. In vitro
antiproliferative, apoptoic and antioxidative activities of
puricalagin, ellagic and a total pomegranate tannin extract are
enhanced in combination with other polyphenols as found in
pomegranate juice. Jun 1 2005;16(6):360--7.
14. Lansky EP, Harrison G, Froom P, et al. Pomegranate (Punica
granatum) pure chemicals show possible synergistic inhibition
of human PC-3 prostate cancer cell invasion across MatrigelTM.
Invest New Drug Jan 1 2005;23(2):121--2.
15. Reference 8:40, PD136.
16. Tung oil -- Wikipedia, the free encyclopaedia. At: http://
17. Tran HNA, Bae SY, Song BH, et al. Pomegranate (Punica
granatum) seed linolenic acid isomers. Concentration-
dependent modulation of estrogen receptor activity. Endocr
18. Bown D. The Royal Horticultural Society encyclopedia of herbs
and their uses. London 1995. BCA (Dorling Kindersley.);338.
19. Gasmi J, Sanderson JT. Growth inhibitory, anti-androgenic and
pro-apoptoic effects of punicic acid in LNCaP human prostate
cancer cells. J Agr Food Chem. Dec 8 2010;58(23):12149--56.
20. Landete JM. Ellagitannins, ellagic acid and their derived
metabolites. A review about source, metabolism, functions and
health. Food Res Int. Jun 1 2011;44(5):1150--60.
21. Larosa M, Gonzalez-Sarias A, Garcia-Conesa MT, et al. Urolithins,
ellagic acid-derived metabolites produced by human colonic
microflora, exhibit estrogenic and antiestrogenic activities. J
Agric Food Chem. Mar 8 2006;54(5):1611--20.
22. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D. Urolithins,
intestinal microbial metabolites of Pomegranate ellagitannins,
exhibit potent antioxidant activity in a cell-based assay. J Agric
Food Chem. Nov 11 2009;57(21):10181--6.
23. Kasimsetty SG, Bialonska D, Reddy MK, et al. Effects of
pomegranate chemical constituents/intestinal microbial
metabolites on CYP1B1 in 22Rv1 prostate cancer cells. J Agric
Food Chem. Nov 25 2009;57(22):10636--44.
24. Pantuck AJ, Leppert JT, Zomorodian N, et al. Phase II study of
pomegranate juice for men with rising prostate-specific antigen
(PSA) following surgery or radiation for prostate cancer. Clin
Cancer Res. Jul 1 2006;12(13):4018--26.
25. Bishayee A, Bhatia D, Thoppil RJ, et al. Pomegranate medicated
chemoprevention of experimental hepatocarcinogenesis
involves Nrf2-regulated antioxidant mechanisms.
Carcinogenesis Jun 1 2011;32(6):888--96.
Bisolvon has expanded its product
portfolio with the launch of Bisolvon
Chesty Kids Strawberry Liquid (Bisolvon
Chesty Kids) and Bisolvon Dry Honey
Lime Pastilles (Bisolvon Dry Pastilles)
in the lead up to the winter 2012 cold
and flu season. Bisolvon Chesty Kids
(bromhexine) has been formulated
to maximise compliance among
youngsters with a chesty cough.
According to the company it delivers
the same effective action as Bisolvon
Chesty thinning mucus down and
helping to clear the chest. Strawberry is
the flavour that pharmacists believe is
most important when treating children.1
Bisolvon is the only brand to offer
bromhexine in three different formats
-- tablets, liquid and fast-dissolving
To complement the existing Bisolvon
Dry range, Boehringer Ingelheim has
also launched Bisolvon Dry Honey Lime
Pastilles. The convenient on-the-go
formula contains the same proven
ingredient (dextromethorphan) as the
Bisolvon Dry formulation which reduces
the urge to cough.
Bisolvon Senior Brand Manager, Sally
Binfield, said the new offerings will
be backed by Boehringer Ingelheim's
ongoing support for pharmacy. 'Our
investment in marketing and our
determination to encourage consumers
to consult their pharmacist plays
a key role in our ongoing support
for pharmacy. In 2012 we have
committed over $2 million on Bisolvon
TV advertising and will continue to
grow our online presence to educate
sufferers. In addition we will continue
our pharmacy education programs
and in-store promotional activities.
As a partner in care with community
pharmacy Bisolvon is committed to
providing the necessary support for
Australian pharmacists to address their
1. IMS Health, Boehringer Ingelheim, Pharmacist Survey,
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