Home' Australian Pharmacist : Australian Pharmacist October 2012 Contents Australian Pharmacist October 2012 I © Pharmaceutical Society of Australia Ltd.
OLD DRUG NEW INDICATION
The most recent gabapentin study
was a randomised, double-blind,
placebo-controlled trial undertaken
in an outpatient clinic in Australia.
Adults with refractory chronic cough
(>8 weeks’ duration) without active
respiratory disease or infection were
randomly assigned to receive gabapentin
(maximum tolerable daily dose of
1800 mg) or matching placebo for
10 weeks. The primary endpoint for the
study was a change in cough-specific
quality of life scores from baseline to
eight weeks of treatment.
A total of 62 patients were randomly
assigned to gabapentin (n=32)
or placebo (n=30). Gabapentin
significantly improved cough-specific
quality of life compared with placebo
(NNT = 3·58). Side-effects occurred in
31% of gabapentin patients (the most
common being nausea and fatigue) and
10% of placebo patients. Overall the
results demonstrated that the treatment
of refractory chronic cough with
gabapentin was both effective and well
tolerated and that the potential ‘central
reflex sensitisation mechanism’ seems
to be a potentially relevant pathway in
refractory chronic cough.
• Ryan NM, Birring SS, Gibson PG.
Gabapentin for refractory chronic
cough: a randomised, double-blind,
placebo-controlled trial. Lancet.
2012 Aug 27. [Epub ahead of print]
• Chung KF. Currently available cough
suppressants for chronic cough.
Lung. 2008;186 Suppl 1:S82–7.
• Chung KF. Clinical cough VI: the
need for new therapies for cough:
disease-specific and symptom-
related antitussives. Handb Exp
• Mintz S, Lee JK. Gabapentin in the
Treatment of Intractable Idiopathic
Chronic Cough: Case Reports. AJM
• Lee B, Woo P. Chronic cough as a sign
of laryngeal sensory neuropathy:
diagnosis and treatment. Ann
Otol Rhinol Laryngol. 2005
Unstick bacterial conjunctivitis with
the proven efficacy of Chlorsig.
PBS Information: This product is listed on the PBS
as an anti-infective for ophthalmological use.
Please Review Product Information before prescribing.
Full Product Information is available
from Aspen Pharmacare upon request.
Abridged Product Information: Chlorsig® (chloramphenicol). Indications: For the treatment of bacterial conjunctivitis.
Contraindications: Hypersensitivity and/or toxic reaction to the drug. Precautions: Bone marrow hypoplasia, including
aplastic anaemia and death, has been rarely reported following local application of chloramphenicol. Chloramphenicol should
not be used when less potentially dangerous agents would be expected to provide effective treatment. Ophthalmic agents
may retard corneal wound healing. Eye pain/injury, severe ocular infections, contact lenses, dry eye syndrome, glaucoma,
concomitant use of other ocular medications, surger y or laser within the last 6 months. See full PI. Adverse Effects: Local
irritation (itching/burning), angioneurotic oedema; anaphylaxis, urticaria, fever, vesicular and maculopapular dermatitis, blood
dyscrasias. Pregnancy Category: A. Dosage and administration: Eye Drops. Adults and children (2 years and over):
Instil 1 or 2 drops in the affected eye( s) ever y two to six hours for up to 5 days. Eye Ointment. Adults and children (2 years and
over): Apply 1.5 cm into lower eye lid of the affected eye every three hours for up to 5 days. Chlorsig is not recommended for
children under 2 years except on medical advice. Presentation : Eye Drops. Store between 2-8°C until opened. Refrigerate.
Do not freeze. On opening, the drops may be stored at room temperature (below 25°C). Eye Ointment. Store below 25°C.
PBS Dispensed Price: Eye Drops $11.10, Eye Ointment $ 9.86 . Schedule: S3. ® Chlorsig is a registered trademark of
Aspen Pharma Pty Ltd. Aspen Australia is a group of companies including Aspen Pharma Pty Ltd (ABN 88 004 118 594).
References: 1. Chlorsig Product Information (Oct, 2010). 2. Rose PW et al. Lancet 2005; 366:37-43. 3 .
Miller IM et al. Eye ( Lond). 1992; 6 (Pt 1):111-4 . All sales and marketing
requests to: Aspen Pharma Pty Ltd, 34-36 Chandos Street, St Leonards
NSW 2065 | Tel +61 2 8436 8300. firstname.lastname@example.org |
13/09/12 5:37 PM
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