Home' Australian Pharmacist : Australian Pharmacist September 2014 Contents Australian Pharmacist September 2014 I © Pharmaceutical Society of Australia Ltd.
CONTINUING PROFESSIONAL DEVELOPMENT
KNOWLEDGE IN PRACTICE
The challenge of applying what
you learn to pharmacy practice!
Knowledge in practice is designed to
be difficult and aims to make you apply
information from articles in this month’s
Australian Pharmacist and other suggested
reading to the questions below, just as you
would for a client/patient. This section is not
meant to be easy. There are no simple clear-
cut answers to the questions. The standard
references listed below may be of use when
answering the questions.
1. Sansom L (ed). Australian Pharmaceutical
Formulary and Handbook, 22nd Ed. Canberra:
Pharmaceutical Society of Australia, 2012.
2. Rossi S (ed). Australian Medicines Handbook. Adelaide:
Australian Medicines Handbook; 2014.
3. National Prescribing Service [online]. At: www.nps.org.au
4. Merck Manual of Diagnosis and Therapy [online].
5. Product information – available from various
sources, e.g. MIMS, APP Guide or online on
6. Royal College of Pathologists of Australasia. RCPA
Manual [online]. At: www.rcpamanual.edu.au
7. Therapeutic Guidelines Series. eTG complete [CD-
ROM]. Melbourne: Therapeutic Guidelines Limited.
Knowledge in practice
TO ANSWER KNOWLEDGE IN
Answers for Knowledge in practice can only be
submitted online through the PSA members-only
area of the PSA website at: www.psa.org.au
PSA members will receive instant feedback on
the correct answers with an explanation of why
the answer is correct. If you do not have member
access details for the PSA website, you can request
them via a link from the login page.
Question 1. Migraine
Additional reference: Borghol A, Charles B, Hawawini F.
Pharmacologic and complementary therapy for migraine
prophylaxis. US Pharm 2013;38(1):23–6. At: http://tinyurl.com/
Mrs Clarence (51 years old) suffers from
frequent severe migraines (at least
once a week). She has a history of
angina, hypercholesterolaemia and
closed-angle glaucoma, and her BMI is
30. The metoprolol that she takes for her
angina has not prevented her migraines.
Her current medications are:
• aspirin 100 mg daily
• metoprolol 100 mg twice daily
• atorvastatin 20 mg daily
• glyceryl trinitrate 600 mcg
1 sublingually when required
• Anagraine (metoclopramide
hydrochloride 5 mg and paracetamol
500 mg) 1–2 when required.
Which of the following would be the
MOST appropriate to recommend
for consideration by the GP to use as
migraine prophylaxis for Mrs Clarence?
a) Amitriptyline 10 mg daily, increasing to
75 mg daily.
b) Topiramate 25 mg daily, increasing to
25–50 mg twice daily.
c) Naratriptan 1 mg twice daily.
d) Pizotifen 500 mcg daily, increasing to
1.5 mg daily.
Question 2. Interpreting
clinical trial results
Additional reference: NPS MedicineWise. Questions to ask
when evaluating a new drug. 2013. At: http://tinyurl.com/
A recent randomised controlled trial
compared a new cancer drug (beta) with
an older drug (alpha). In the 12-month
trial, 4,000 patients were randomly
allocated to two equal treatment
groups. During this period, patient
deaths were 200 in the alpha group and
140 in the beta group.
Use this data to identify the CORRECT
a) For patients in the alpha treatment
group, the risk of dying during the trial
b) Patients in the beta treatment group had
a 3% lower chance of dying than patients
in the alpha group.
c) The relative risk of dying was reduced
by 70% for patients in the beta group
compared with patients in the alpha
d) If drug beta is used instead of drug alpha
in 60 patients for one year, one less
patient will die.
Through successful completion of this activity, the
learner will demonstrate their ability to:
• Use readily available information sources to
access and select relevant and up-to-date
clinical and practice based information
• Promote and contribute to the optimal use of
• Address primary healthcare needs of patients.
Competency standards (2010) addressed: 4.2, 6.1,
7.1, 7.2 .
Accreditation number: CAP140909F-G
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